Uric acid and its association with cardiovascular disease

Abstract

Hyperuricemia is commonly associated with traditional risk factors such as abnormalities in glucose metabolism, dyslipidemia, and hypertension. Recent studies have revived the controversy over the role of serum uric acid (UA) as an independent prognostic factor for cardiovascular mortality. We study the relationship between increase of UA and the cardiovascular disease. In order to assess this relation, we measure muscular brain creatinine kinase enzyme (CK_mb) and troponin I (Tr.I) as a two parameters to prove the cardiovascular abnormalities of the study samples. The study was included 62 patients in total and the laboratory results, shows there is 37 case with high UA and 25 case with normal UA record. On the other hand, the increase of troponin I which used as a diagnostic parameter to assess the cardiovascular cases was found increased in 13 sample concurrent with an increase of UA. Nevertheless, the another 11 samples were within normal level of UA but was concurred with high troponin I. Statistical evaluation of UA results was revealed a significant increase of mean ± SD (8.8 ± 2.9 mg/dL) and the p. value were < 0.05 (p=0.032). The samples result of high UA, high Ck_mb and high troponin I, prove the previous studies which find there is a relationship between the cardiovascular disease and increase of UA. Therefore, addressing this phenomenon will be of interest to investigate further.